It takes a big man to admit when he’s wrong, but no one could be expected to believe that billionaire Trump antagonizer Mark Cuban might fall into that category.
Cuban, who made his fortunes after founding Cost Plus Drugs to facilitate director-to-consumer sales of pharmaceuticals, said on Wednesday that some of President Donald Trump’s executive orders are in line with his push to democratize the sale of medicines that for years have been prohibitively expensive for seniors.
Trump’s EO “on healthcare and in particular, drug pricing could save hundreds of billions,” the entrepreneur wrote on social media.
Both men appear to agree that pharmacy benefit managers, the much-maligned middlemen of healthcare, are an unnecessary barrier to obtaining critical medicines. The industry’s proliferation of PBMs has been called out for its concurrent increase while the price of many mainstream drugs has done the same.
Under Trump’s order, pricing formularies will be divorced the the outcomes of PBMs.
“Make them about wellness, not pay for play like a grocery store endcap. This ends rebates and allows for net pricing. It also allows for better care and wellness,” Cuban stated.
In addition, President Trump is requiring PBMs to report all data to the employers, states, and manufacturers responsible for paying many of the bills. No longer can the middlemen cherrypick which data points they cite in deciding whether a drug is efficacious and should be made widely available.
Trump’s EO also eliminates a category for “special drugs,” one Cuban has long accused of being a superfluous designation.
“There is nothing special about specialty drugs. They call them special to jack up the price,” he wrote.
Other reforms, including the ability of pharmacies to inflate the price of generics and the elimination of confidentiality clauses preventing companies from talking directly with drug manufacturers about their prices, are right on target, he added.
Should Trump need any industry expertise, Cuban said he would willingly provide it.
“Put me in coach! I’m here to help,” he joked.


Cuban’s one-way bonhomie is a far cry from his remarks about Trump as a surrogate for the Harris campaign last year. Then, the self-described centrist capitalist got himself in hot water for sententiously moralizing about the women seen around Trump.
“You never see him around strong, intelligent women,” Cuban said during an appearance on ABC’s “The View.” “Ever. It’s just that simple.”
The careless remark prompted scores of conservative women to rebuke Cuban for discounting their intelligence and graduate degrees based on their looks.
And despite railing against the changes on X after Elon Musk’s takeover, Cuban continues to voice his opinions on a near-daily basis to his nine million followers. Some of those utterances have led to direct clashes with Musk, a frequent poster himself.
After chiding Musk for eliminating diversity, equity, and including policies at the social media company, other users began to ask Musk why he wasn’t putting DEI policies to work in the starting lineup of the Dallas Mavericks, his NBA team.
Musk, chiming him, replied to one, “Mark Cuban is desperately trying to signal his ‘virtue’, but his hypocrisy convinces no one.”